主要从事生物荧光探针、生物医学材料化学、活性分子合成等领域的研究

一、科研项目

1. 国家基础科学人才培养基金（J1210004），四川大学放射化学特殊学科点项目，项目负责人，2013.01~2015.12，经费：300万元。

2. 教育部高等学校博士点专项科研基金优先资助领域项目（20120181130006），纳米金负载多胺或大环多胺基因转染载体的研究，项目负责人，2013.1~2015.12，经费：40万元。

3. 973课题（2012CB720603），基于核酸的重大疾病诊断新策略和新技术研究，四川大学项目负责人，2012.01~2015.12，经费：50万元。

4. 国家自然科学基金创新研究群体项目（21321061），目标导向的有机合成和新反应，研究骨干，2014.01~2016.12，经费：600万元。

5. 国家自然科学基金重点项目（21232005），生物大分子特异识别与调控的有机小分子研究，项目负责人，2013.01~2017.12，经费：300万元。

6. 973课题（2013CB328900），微波加热工艺物料机理与多物理场协同计算，四川大学项目负责人，2013.01-2017.12，经费：180万元。

7. 教育部基础学科拔尖学生培养试验计划研究重点项目，以科研为依托的化学类本科拔尖创新人才培养模式探索与实践，项目负责人，2016.01~2018.12，经费：18万元。

8. 国家自然科学基金面上项目（21472131），多肽修饰聚乙烯亚胺基因载体的研究，项目负责人，2015.01~2018.12，经费：90万元。

9. 国家自然科学基金面上项目（21877082），ROS响应的siRNA自递送系统的构建及应用，项目负责人，2019.01~2022.12，直接经费：67万元。

二、获奖情况

1. 化学类拔尖人才国际化培养模式的探索与实践，第八届高等教育四川省教学成果二等奖，2017. 12

2. 基于科研引导的研究型大学化学本科创新人才培养体系与实践，第七届高等教育四川省教学成果一等奖，2013. 12

3. 天然药物有效成分分离、类似物合成及药效和临床应用研究，四川省科技进步二等奖，2012.08

4. 简单金属盐催化的C-C键和C-N键形成反应，教育部高等学校科学研究优秀成果奖自然科学一等奖，2010.11

5. 金属胶束模拟水解金属酶的研究，四川省科技进步二等奖，2006.07

6. 生物功能体系的分子模拟，四川省科技进步三等奖，2001.07

三、编撰书目

1. Xiaoqi Yu，Ji Zhang，《Macrocyclic Polyamines: Synthesis and Applications》，Wiley-VCH，2017.12, ISBN: 978-3-527-34187-0

四、授权发明专利

1. 环氧化合物与阳离子聚合物及它们的制备方法, 授权专利号：ZL2012 1 0586561.5, 第一发明人

2. 固定化土曲霉脂肪酶的制备方法及其应用, 授权专利号：ZL2013 1 0752140.X,  第一发明人

3. 取代的水杨醛-TCF衍生物及其制备方法和用途, 授权专利号：ZL2014 1 0023272.3, 第一发明人

4. 取代的香豆素-吡啶衍生物及其制备方法和用途, 授权专利号：ZL201510618120.2, 第一发明人

5. 环氧化合物与阳离子聚合物及它们的制备方法，授权专利号：ZL2012 1 0586561.5，第一发明人

6. 固定化土曲霉脂肪酶的制备方法及其应用，授权专利号：ZL2013 1 0752140.X，第一发明人

7. 取代的水杨醛-TCF衍生物及其制备方法和用途, 授权专利号：ZL2014 1 0023272.3，第一发明人

8. 取代的香豆素-吡啶衍生物及其制备方法和用途，授权专利号：ZL201510618120.2，第一发明人

9. 取代的香豆素-噻唑橙衍生物及其制备方法和用途，授权专利号：ZL 201510852034.8，第一发明人

10. 取代的咔唑-吲哚磺酸盐衍生物及其制备方法和用途，授权专利号：ZL 201510618052.X，第一发明人

五、近五年发表的论文

1. 1. Li, K., Li, L.-L., Zhou, Q., Yu, K.-K., Kim, J. S., Yu, X.-Q.*,Reaction-based fluorescent probes for SO₂ derivatives and their biological applications, Coordin. Chem. Rev.2019, 388, 310-333.

2. 2. He, X., Chen, P., Zhang, J., Luo, T.-Y., Wang, H.-J., Liu, Y.-H., Yu, X.-Q.*,Cationic Polymer-Derived Carbon Dots for Enhanced Gene Delivery and Cell Imaging, Biomater. Sci.2019, 7, 1940-1948.

3. 3. Li, L.-L., Xu, H.-R., Li, K., Yang, Q., Pan, S.-L., Yu, X.-Q.*,Mitochondrial G-quadruplex targeting probe with near-infrared fluorescence emission, Sensor. Actuat. B: Chem.2019, 286, 575-582.

4. 4. Jiang, L., Tian, J., Zhao, F., Yu, S.-S., Shi, D., Wang, X.-J., Yu, X.-Q.*, Pu, L., Fluorescent Recognition of Functional Secondary Amines in the Fluorous Phase, Eur. J. Org. Chem.2019, 14, 2533-2538.

5. 5. Gu, B., Hu, Z.-E., Yang, Z.-J., Li, J., Zhou, Z.-W., Wang, N., Yu, X.-Q.*,Probing the Mechanism of CAL-B-Catalyzed aza-Michael Addition of Aniline Compounds with Acrylates Using Mutation and Molecular Docking Simulations, ChemistrySelect2019, 4, 3848-3854.

6. 6. Feng, M.-L., Li, S.-Q., He, H.-Z., Xi, L.-Y., Chen, S.-Y., Yu, X.-Q.*,Electrochemically initiated intermolecular C–N formation/cyclization of ketones with 2-aminopyridines: an efficient method for the synthesis of imidazo[1,2-a]pyridines, Green Chem.2019, 21, 1619-1624.

7. 7. Yang, X.-L., Xing, X., Li, J., Liu, Y.-H., Wang, N., Yu, X.-Q.*,Enzymatic synthesis of selenium-containing amphiphilic aliphatic polycarbonate as an oxidation-responsive drug delivery vehicle, RSC Adv.2019, 9, 6003-6010.

8. 8. Li, L.-L., He, P.-Y., Shi, L., Pan, S.-L., Li, M.-Y., Zhou, Q., Zhang, H., Wang, N., Li, K., Yu, X.-Q.*,A near-infrared water-soluble fluorescent probe for the detection of biothiols in living cells and Escherichia coli, Anal. Methods2019, 11, 821-826.

9. 9. He, W.-X., Xing, X., Yang, Z.-J., Yu, Y., Wang, N., Yu, X.-Q.*,Biocatalytic One-Pot Three-Component Synthesis of Indoloquinolizines with High Diastereoselectivity, Catal. Lett.2019, 149, 638-643.

10. 10. Xing, X., Jia, J.-Q., Zhang, J.-F., Zhou, Z.-W., Li, J., Wang, N., Yu, X.-Q.*,CALB Immobilized onto Magnetic Nanoparticles for Efficient Kinetic Resolution of Racemic Secondary Alcohols: Long-Term Stability and Reusability, Molecules2019, 24, 490.

11. 11. Wang, N., Chen, X.-C., Ding, R.-L., Yang, X.-L., Li, J., Yu, X.-Q.*, Li, K., Wei, X. Synthesis of high drug loading, reactive oxygen species and esterase dual-responsive polymeric micelles for drug delivery, RSC Adv. 2019, 9, 2371-2378.

12. 12. Yu, Q.-Y., Guo, Y., Zhang, J., Huang, Z., Yu, X.-Q.*,Zn(II) coordination to cyclen-based polycations for enhanced gene delivery, J. Mater. Chem. B2019, 7, 451-459.

13. 13. Xiao, Y.-P., Zhang, J., Liu, Y.-H., Zhang, J.-H., Yu, Q.-Y., Huang, Z., Yu, X.-Q.*,Low molecular weight PEI-based fluorinated polymers for efficient gene delivery, Eur. J. Med. Chem.2019, 162, 602-611.

14. 14. Qin, H.-H., Li, L.-L., Li, K., Yu, X.-Q.*,Novel strategy of constructing fluorescent probe for MAO-B via cascade reaction and its application in imaging MAO-B in human astrocyte, Chin. Chem. Lett.2019, 30, 71-74.

15. 15. Shi, L., Li, K., Li, L.-L., Chen, S.-Y., Li, M.-Y., Zhou, Q., Wang, N., Yu, X.-Q.*,Novel easily available purine-based AIEgens with colour tunability and applications in lipid droplet imaging, Chem. Sci. 2018, 9, 8969-8974.

16. 16. Zhou, Q., Li, K., Liu, Y.-H., Li, L.-L., Yu, K.-K., Zhang, H., Yu, X.-Q.*,Fluorescent Wittig reagent as a novel ratiometric probe for the quantification of 5-formyluracil and its application in cell imaging, Chem. Commun. 2018, 54, 13722-13725.

17. 17. Li, J., Yang, X.-L., Liu, Y.-H., Wu, W.-X., Liu, B.-Y., Wang, N., Yu, X.-Q.*, Chemoenzymatic synthesis of dual-responsive graft copolymers for drug delivery: long-term stability, high loading and cell selectivity, J. Mater. Chem. B 2018, 6, 6993-7003.  

18. 18. Zhang, J.-H., Yang, H.-Z., Zhang, J., Liu, Y.-H., He, X., Xiao, Y.-P., Yu, X.-Q.*,Biodegradable Gene Carriers Containing Rigid Aromatic Linkage with Enhanced DNA Binding and Cell Uptake, Polymers2018, 10, 1080.

19. 19. Xun, M.-M., Huang, Z., Xiao, Y.-P., Liu, Y.-H., Zhang, J., Zhang, J.-H., Yu, X.-Q.*,Synthesis and Properties of Low-Molecular-Weight PEI-Based Lipopolymers for Delivery of DNA, Polymers2018, 10, 1060.

20. 20. Iqbah, S., Yu, S., Zhao, F., Wang, Y., Tian, J., Jiang, L., Du, Y., Yu, X.-Q.*, Pu, L. Discriminating three biothiols by using one fluorescent probe, Tetrahedron Lett.2018, 59, 3397-3400.

21. 21. Zhang, Y.-M, Huang, Z., Wu, X.-R., Zhang, J., Liu, Y.-H., Yu, X.-Q.*,A small combinatorial library of lipidoids as gene delivery vectors, ACS Appl. Nano Mater.2018, 1, 3925-3934.

22. 22. Shi, L., Li, K., Cui, P.-C., Li, L.-L., Pan, S.-L., Li, M.-Y., Yu, X.-Q.*,BINOL Derivatives with Aggression-induced Emission, J. Mater. Chem. B 2018, 6, 4413-4416.

23. 23. Wang, X.-J., Shi, D., Xu, Y., Yu, S., Zhao, F., Wang, Y., Hu, L., Tian, J., Yu, X.-Q.*, Pu, L. Reaction of Zn(II) with a BINOL-amino-acid Schiff base: An unusual off-on-off fluorescence response, Tetrahedron Lett. 2018, 59, 2332-2334.

24. 24. Li, M.-Y., Cui, P., Li, K., Feng, J., Zou, M., Yu, X.-Q.*,Dual-site fluorescent probe for highly selective and sensitive detection of sulfite and biothiols, Chin. Chem. Lett. 2018, 29, 992-994.

25. 25. Pan, S.-L., Li, K., Li, L.-L., Li, M.-Y., Shi, L., Liu, Y.-H., Yu, X.-Q.*,A reaction-based ratiometric fluorescent sensor for the detection of Hg(II) ions in both cells and bacteria, Chem. Commun. 2018, 54, 4955-4958.

26. 26. Li, L.-L., Li, K., Li, M.-Y., Shi, L., Liu, Y.-H., Zhang, H., Pan, S.-L., Wang, N., Zhou, Q., Yu, X.-Q.*,BODIPY-Based Two-Photon Fluorescent Probe for Real-Time Monitoring of Lysosomal Viscosity with Fluorescence Lifetime Imaging Microscopy, Anal. Chem. 2018, 90, 5873-5878.

27. 27. Wang, B., Zhang, J., Liu, Y.-H., Zhang, W., Xiao, Y.-P., Zhao, R.-M., Yu, X.-Q.*,A reduction-responsive liposomal nanocarrier with self-reporting ability for efficient gene delivery, J. Mater. Chem. B 2018, 6, 2860-2868.

28. 28. Hu, L.-L., Wang, Y., Duan, P., Du, Y., Tian, J., Shi, D., Wang, X.-J., Yu, S., Yu, X.-Q.*, Pu, L., Fluorescent Discrimination of Primary Alkyl Amines by Using a Binaphthyl Ladder Polymer, Eur. J. Org. Chem. 2018, 16, 1896-1901.

29. 29. Zhao, F., Du, Y., Tian, J., Shi, D., Wang, Y., Hu, L., Yu, S., Yu, X.-Q.*, Pu, L., Enantioselective Fluorescent Recognition of Amino Acids in Aqueous Solution by Using a Chiral Aldehyde Probe, Eur. J. Org. Chem. 2018, 16, 1891-1895.

30. 30. Zhang, W., Wang, N., Yu, Y., Shan, Y.-M., Wang, B., Pu, X.-M., Yu, X.-Q.*,Synthetic Regulation of 1,4-Dihydropyridines for the AIE or AIEE Effect: From Rational Design to Mechanistic Views, Chem. Eur. J. 2018, 24, 4871-4878.

31. 31. Shi, D., Wang, X.-J., Yu, S.-S., Zhao, F., Wang, Y.-C., Tian, J., Hu, L.-L, Yu, X.-Q.*, Pu, L., Fluorescent Recognition of 1,3-Diaminopropane in the Fluorous Phase – Greatly Enhanced Sensitivity and Selectivity, Eur. J. Org. Chem. 2018, 8, 1053-1059.

32. 32. Luo, T.-Y., He, X., Zhang, J., Chen, P., Liu, Y.-H., Wang, H.-J., Yu, X.-Q.*,Photoluminescent F-doped Carbon Dots Prepared by Ring-Opening Reaction for Gene Delivery and Cell Imaging, RSC Adv. 2018, 8, 6053-6062.

33. 33. Huang, Z., Zhao, D.-M., Deng, X., Zhang, J., Zhang, Y.-M., Yu, X.-Q.*,Functionalized asymmetric bola-type amphiphiles for efficient gene and drug delivery, Nanomaterials 2018, 8, 115.

34. 34. Xiao, Y.-P., Zhang, J., Liu, Y.-H., Chen, X.-C., Yu, Q.-Y., Luan, C.-R., Zhang, J.-H., Wei, X., Yu, X.-Q.*,Ring-opening polymerization of diepoxides as an alternative method to overcome PEG dilemma in gene delivery, Polymer 2018, 134, 53-62.

35. 35. Wang, B., Chen, P., Zhang, J., Liu, Y.-H., Huang, Z., Yu, Q.-Y., Zhang, J.-H., Zhang, W., Yu, X.-Q.*, Self-assembled core-shell-corona multifunctional AIE non-viral vector for efficient hepatocytes targeting gene delivery, Polymer Chem. 2017, 8, 7486-7498.

36. 36. Wang, Y.-C., Hu, L.-L., Zhao, F., Yu, S.-S., Tian, J., Shi, D., Wang, X.-J., Yu, X.-Q.*, Pu, L., Polymer Amplified Enantioselectivity in the Fluorescent Recognition of Prolinol, Chem. Eur. J. 2017, 23, 17678-17681.

37. 37. Xiao, Y.-P., Zhang, J., Liu, Y.-H., Huang, Z., Wang, B., Zhang, Y.-M., Yu, X.-Q.*, Cross-linked polymers with fluorinated bridge for efficient gene delivery, J. Mater. Chem. B 2017, 5, 8542-8553.

38. 38. Liu, B.-Y., Wu, W.-X., Liu, Y.-H., Jia, C., Yang, X.-L., Li, J., Wang, N., Yu, X.-Q.*, Water-soluble mitochondria-targeting polymeric prodrug micelles for fluorescence monitoring and high intracellular anticancer efficiency, Polym. Chem. 2017, 8, 5982-5987.

39. 39. Zhang, W., Wang, N., Yang, Z.-J., Li, Y.-R., Yu, Y., Pu, X.-M., Yu, X.-Q.*, Lipase-Initiated Tandem Biginelli Reactions via in situ-Formed Acetaldehydes in One Pot: Discovery of Single-Ring Deep Blue Luminogens, Adv. Synth. Catal. 2017, 359, 3397-3406.

40. 40. Xu, Y.-M., Shi, D., Wang, X.-J., Yu, S.-S., Yu, X.-Q.*, Pu, L., Development of Aldehyde-Based Fluorescent Probes for Highly Selective Recognition of 1,3-Diaminopropane, Eur. J. Org. Chem. 2017, 33, 4990-4994.

41. 41. Yu, Q.-Y., Zhan, Y.-R., Zhang, J., Luan, C.-R., Wang, B., Yu, X.-Q.*, Aromatic modification of low molecular weight PEI for enhanced gene delivery, Polymers 2017, 9, 362.

42. 42. Wang, B., Zhao, R.-M., Zhang, J., Liu, Y.-H., Huang, Z., Yu, Q.-Y., Yu, X.-Q.*, Rigid aromatic linking moiety in cationic lipids for enhanced gene transfection efficiency, Eur. J. Med. Chem. 2017, 136, 585-595.

43. 43. Hu, L.-L., Yu, S.-S., Wang, Y.-C., Yu, X.-Q.*, Pu, L., Enhanced Fluorescence of 3,3′-Diformyl BINOL by Functional Secondary Amines, Org. Lett. 2017, 19, 3779-3782.

44. 44. Yang, J., Li, K., Hou, J.-T., Lu, C.-Y., Li, L.-L., Yu, K.-K., Yu, X.-Q.*, A novel coumarin-based water-soluble fluorescent probe for endogenously generated SO₂ in living cells, Sci. China Chem. 2017, 60, 793-798.

45. 45. Feng, M.-L., Xi, L.-Y., Chen, S.-Y., Yu, X.-Q.*, Electrooxidative Metal-Free Dehydrogenative α-Sulfonylation of 1H-Indole with Sodium Sulfinates, Eur. J. Org. Chem. 2017, 19, 2746-2750.

46. 46. Li, K., Hou, J.-T., Yang, J., Yu, X.-Q.*, A tumor-specific and mitochondria-targeted fluorescent probe for real-time sensing of hypochlorite in living cells, Chem. Commun. 2017, 53, 5539-5541.

47. 47. Wang, H.-J., He, X., Luo, T.-Y., Zhang, J., Liu, Y.-H., Yu, X.-Q.*, Amphiphilic carbon dots as versatile vector for nucleic acid and drug delivery, Nanoscale. 2017, 9, 5935-5947.

48. 48. Jiang, C., Li, L.-L., Yu, X.-Q.*, A pyrene-based fast-responsive fluorescent probe for G-quadruplexes, Anal. Methods 2017, 9, 2397-2400.

49. 49. Chen, L.-M., Yu, S.-S., Xiao, M., Huang, Z., Wen, K.-L., Xu, Y.-M., Zhao, F., Yu, X.-Q.*, Pu, L., Recognition of Chiral Amines by a Terpyridine–ZnII-Complex-Based Circular-Dichroism Sensor, Eur. J. Org. Chem. 2017, 16, 2338-2343.

50. 50. Hou, J.-T., Ren, W. X., Li, K., Seo, J., Sharma, A., Yu, X.-Q.*, Kim, J. S., Fluorescent bioimaging of pH: from design to applications, Chem. Soc. Rev. 2017, 46, 2076-2090.

51. 51. Chang, D.-C., Zhang, Y.-M, Zhang, J., Liu, Y.-H., Yu, X.-Q.*, Cationic lipids with cyclen headgroup: Synthesis and structure-activity relationship studies as non-viral gene vectors, RSC Adv. 2017, 7, 18681-18689.

52. 52. Zhang, Y.-M, Huang, Z., Zhang, J., Wu, W.-X., Liu, Y.-H., Yu, X.-Q.*, Amphiphilic polymers from ring-opening polymerization: a strategy for the enhancement of gene delivery, Biomater. Sci. 2017, 5, 718-729.

53. 53. Wang, S., Chen, S.-Y., Yu, X.-Q.*, C–H functionalization by high-valent Cp*Co(III) catalysis, Chem. Commun.2017, 53, 3165-3180.

54. 54. Xiao, M., Yu, S., Chen, L., Huang, Z., Wen, K., Xu, Y., Zhao, F., Yu, X.-Q.*, Pu, L. Fluorous-Phase-Based Chiral Assay with Circular Dichroism Spectroscopy, Eur. J. Org. Chem.2017, 11, 1413-1417.

55. 55. Jia, J.-Q., Zhang, W.-W., Yang, Z.-J., Yang, X.-L., Wang, N., Yu, X.-Q.*, Novel Magnetic Cross-Linked Cellulase Aggregates with a Potential Application in Lignocellulosic Biomass Bioconversion, Molecules2017, 22, 269.

56. 56. Wang, H.-J.,Zhang, J., Liu, Y.-H., Luo, T.-Y., He, X., Yu, X.-Q.*, Hyaluronic acid based carbon dots for efficient gene delivery and cell imaging, RSC Adv.2017, 7, 15613-15624.

57. 57. Zhang, W., Wang, N., Liu, Y.-H., Jiao, S.-Y., Zhang, W.-W., Pu, X.-M., Yu, X.-Q.*, 1,4-Dihydropyridines: discovery of minimal AIEEgens and their mitochondrial imaging applications, J. Mater. Chem. B2017, 5, 464-469.

58. 58. 李玲玲, 吴明雨, 张宏, 李坤*, 余孝其*，溶酶体靶向的生物硫醇荧光探针的合成及应用研究，Sci Sin Chim, 2017, 47, doi: 10.1360/N032017-00059。

59. 59. 刘艳红，李静，张骥，余孝其*，李坤，阳离子脂质体介导基因转染的实验教学改革，实验科学与技术，2017，15（3），103-106。

60. 60. Luan, C.-R., Liu, Y.-H., Zhang, J.*, Yu, Q.-Y., Huang, Z., Wang, B., Yu, X.-Q.*, Low Molecular Weight Oligomers with Aromatic Backbone as Efficient Nonviral Gene Vectors, ACS Appl. Mater. Interfaces, 2016, 8, 10743−10751.

61. 61. Yu, K.-K., Li, K.*, Qin, H.-H., Zhou, Q., Qian, C.-H., Liu, Y.-H., Yu, X.-Q.*, Construction of pH-Sensitive “Submarine” Based on Gold Nanoparticles with Double Insurance for Intracellular pH Mapping, Quantifying of Whole Cells and in Vivo Applications, ACS Appl. Mater. Interfaces, 2016, 8, 22839−22848.

62. 62. Yang, J., Li, K.*, Hou, J.-T., Li, L.-L., Lu, C.-Y., Xie, Y.-M., Wang, X., Yu, X.-Q.*, Novel Tumor-Specific and Mitochondria-Targeted near-Infrared-Emission Fluorescent Probe for SO₂ Derivatives in Living Cells, ACS Sens., 2016, 1, 166−172.

63. 63. Xi, L.-Y., Zhang, R.-Y., Shi, L., Chen, S.-Y.*, Yu, X.-Q.*, Iodine-mediated synthesis of 3-acylbenzothiadiazine 1,1-dioxides, Beilstein J. Org. Chem., 2016, 12, 1072–1078.

64. 64. Liu, Y., Li, K.*, Xie, K.-X., Li, L.-L., Yu, K.-K., Wang, X., Yu, X.-Q.*, A water-soluble and fast-response mitochondriatargeted fluorescent probe for colorimetric and ratiometric sensing of endogenously generated SO₂ derivatives in living cells, Chem. Commun., 2016, 52, 3430—3433.

65. 65. Wang, S., Hou, J.-T., Feng, M.-L., Zhang, X.-Z., Chen, S.-Y.*, Yu, X.-Q.*, Cobalt(III)-catalyzed alkenylation of arenes and 6-arylpurines with terminal alkynes: efficient access to functional dyes, Chem. Commun., 2016, 52, 2709—2712.

66. 66. Liao, Y.-X., Yang, Z.-X., Li, K.*, Yu, X.-Q.*, A Highly Selective Ratiometric Fluorescent Probe for Peroxynitrite Detection in Aqueous Media, Chem. Lett., 2016, 45, 691–693.

67. 67. Liao, C., Chen, Y., Yao, Y., Zhang, S.*, Gu, Z., Yu, X., Cross-Linked Small-Molecule Micelle-Based Drug Delivery System: Concept, Synthesis, and Biological Evaluation, Chem. Mater., 2016, 28, 7757−7764.

68. 68. Xu, Y., Yu, S.*, Chen, Q., Chen, X., Xiao, M., Chen, L., Yu, X.*, Xu, Y., Pu, L.*, Greatly Enhanced Fluorescence by Increasing the Structural Rigidity of an Imine: Enantioselective Recognition of 1,2-Cyclohexanediamine by a Chiral Aldehyde, Chem. Eur. J., 2016, 22, 5963 – 5968.

69. 69. Xu, Y., Yu, S.*, Chen, Q., Chen, X., Li, Y., Yu, X.*, Pu, L.*, Fluorescent Recognition of 1,2-Diamines by a 1,1’-Binaphthyl-Based Trifluoromethyl Ketone, Chem. Eur. J., 2016, 22, 12061–12067.

70. 70. Zhang, C., Liu, P.-X., Huang, L.-Y., Wei S.-P., Wang, L., Yang, S.-Y., Yu, X.-Q., Pu, L.*, Wang, Q.*, Engineering P450 Peroxygenase to Catalyze Highly Enantioselective Epoxidation of cis-b-Methylstyrenes, Chem. Eur. J., 2016, 22, 10969–10975.

71. 71. Xu, Y., Yu, S*,  Wang, Y., Hu, L., Zhao F., Chen, X., Li, Y., Yu, X.*, Pu, L.*, Ratiometric Fluorescence Sensors for 1,2-Diamines Based on Trifluoromethyl Ketones, Eur. J. Org. Chem., 2016, 5868–5875.

72. 72. Huang, Z., Zhang, Y.-M., Cheng, Q., Zhang, J.*, Liu, Y.-H., Wang, B., Yu, X,-Q,*, Structure–activity relationship studies of symmetrical cationic bolasomes as non-viral gene vectors, J. Mater. Chem. B, 2016, 4, 5575—5584.

73. 73. Yu, Q.-Y., Liu, Y.-H., Huang, Z., Zhang, J.*, Luan, C.-R., Zhang, Q.-F., Yu, X.-Q.*, Bio-reducible polycations from ring-opening polymerization as potential gene delivery vehicles, Org. Biomol. Chem., 2016, 14, 6470–6478.

74. 74. Zhang, R.-Y., Xi, L.-Y., Shi, L., Zhang, X.-Z., Chen, S.-Y.*, Yu, X.-Q.*, Metal-Free Oxidative Radical Alkynylation/Ring Expansion Rearrangement of Alkenyl Cyclobutanols with Ethynylbenziodoxolones, Org. Lett., 2016, 18, 4024−4027.

75. 75. Du, J., Yu, S.*, Huang, Z., Chen, L., Xu, Y., Zhang, G., Chen, Q., Yu, X.*, Pu, L.*, Highly selective ratiometric fluorescent recognition of histidine by tetraphenylethene– terpyridine–Zn(II) complexes, RSC Adv., 2016, 6, 25319–25329.

76. 76. Ran, Y.-Z., Xu, H.-R., Li, K.*, Yu, K.-K., Yang, J., Yu, X.-Q.*, Development of a mitochondria-targeted fluorescent probe for hydrazine monitoring in living cells, RSC Adv., 2016, 6, 111016–111019.

77. 77. Wu, W.-X., Yang, X.-L., Liu, B.-Y., Deng, Q.-F., Xun, M.-M., Wang, N.*, Yu, X.-Q.*, Lipase-catalyzed synthesis of oxidation-responsive poly(ethylene glycol)-b-poly(b-thioether ester) amphiphilic block copolymers, RSC Adv., 2016, 6, 11870–11879.

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89. 89. Jiao, S.-Y., Li, K.*, Zhang, W., Liu, Y.-H., Huang, Z., Yu, X.-Q.*, Cd(II)-terpyridine-based complex as a ratiometric fluorescent probe for pyrophosphate detection in solution and as an imaging agent in living cells, Dalton Trans., 2015, 44, 1358-1365.

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98. 98. Huang, Z., Liu, Y.-H., Zhang, Y.-M., Zhang, J.*, Liu, Q., Yu, X.-Q.*, Cyclen-based cationic lipids containing a pH-sensitive moiety as gene delivery vectors, Org. Biomol. Chem., 2015, 13, 620-630.

99. 99. Xi, L.-Y., Zhang, R.-Y., Zhang, L., Chen, S.-Y.*, Yu, X.-Q.*, An efficient synthesis of quinolines via coppercatalyzed C–N cleavage, Org. Biomol. Chem., 2015, 13, 3924-3930.

100. 100. Jiao, S.-Y., Li, K.*, Wang, X., Huang, Z., Pu, L., Yu, X.-Q.*, Making pyrophosphate visible: the first precipitable and real-time fluorescent sensor for pyrophosphate in aqueous solution, Analyst, 2015, 140, 174-181.

101. 101. Wang, B.-L., Jiang, C., Li, K.*, Liu, Y.-H., Xie, Y.-M., Yu, X.-Q.*, Molecular engineering of a dual emission near-infrared ratiometric fluorophore for the detection of pH at the organism level, Analyst, 2015, 140, 4608-4615.

102. 102. Xu, H.-R., Li, K.*, Jiao, S.-Y., Pan, S.-L., Zeng, J.-R., Yu, X.-Q.*, Tetraphenylethene–pyridine salts as the first self-assembling chemosensor for pyrophosphate, Analyst, 2015, 140, 4182-4188.

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105. 105. Hu, C., Wang, N.*, Zhang, W., Zhang, S., Meng, Y., Yu, X.*, Immobilization of Aspergillus terreus lipase in self-assembled hollownanospheres for enantioselective hydrolysis of ketoprofen vinyl ester, J. Biotechnology, 2015, 194, 12-18.

106. 106. Zhang, W.-W., Yang, X.-L., Jia, J.-Q., Wang, N.*, Hu, C.-L., Yu, X.-Q.*, Surfactant-activated magnetic cross-linked enzyme aggregates (magnetic CLEAs) of Thermomyces lanuginosus lipase for biodieselproduction, J. Mol. Catal. B: Enzymatic, 2015, 115, 83-89.

107. 107. Zhang, W.-W., Jia, J.-Q., Wang, N.*, Hu, C.-L., Yang, S.-Y., Yu, X.-Q.*, Improved activity of lipase immobilized in microemulsion-based organogels for (R,S)-ketoprofen ester resolution: Long-term stability and reusability, Biotechnology Reports, 2015, 7, 1-8.

108. 108. Zhang, R.-Y., Xi, L.-Y., Zhang, L., Chen, S.-Y.*, Yu, X.-Q.*,Metal-free synthesis of ynones via direct CeH alkynylation of aldehydes with ethynylbenziodoxolones, Tetrahedron, 2015, 71, 6176-6182.

109. 109. Ge, D.-L., Zhang, X.-Z., Chen, S.-Y.*, Pu, L., Yu, X.-Q.*, Microwave-assisted synthesis of 2-pyridinylethyl indazoles, Tetrahedron Lett., 2015, 56, 4811-4814.

110. 110. Xu, B., Hou, J., Li, K.*, Lu, Z., Yu, X.*, A BINOL Based Fluorescence Sensor for Distinction of D-Glucose, Chin. J. Chem., 2015, 33, 101-106.

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